Sentinel node in the era of neoadjuvant therapy and locally advanced breast cancer.
Identifieur interne : 008E01 ( Main/Exploration ); précédent : 008E00; suivant : 008E02Sentinel node in the era of neoadjuvant therapy and locally advanced breast cancer.
Auteurs : Steven D. Trocha [États-Unis] ; Armando E. GiulianoSource :
- Surgical oncology [ 0960-7404 ] ; 2003.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Aisselle, Analyse de survie, Biopsie de noeud lymphatique sentinelle, Essais contrôlés randomisés comme sujet, Femelle, Humains, Noeuds lymphatiques (anatomopathologie), Ponction-biopsie à l'aiguille, Pronostic, Protocoles de polychimiothérapie antinéoplasique (administration et posologie), Résultat thérapeutique, Stade de la tumeur, Sujet âgé, Survie sans rechute, Traitement néoadjuvant, Tumeurs du sein (), Tumeurs du sein (anatomopathologie), Tumeurs du sein (mortalité), Tumeurs du sein (traitement médicamenteux), Évaluation des risques.
- MESH :
- administration et posologie : Protocoles de polychimiothérapie antinéoplasique.
- anatomopathologie : Noeuds lymphatiques, Tumeurs du sein.
- mortalité : Tumeurs du sein.
- traitement médicamenteux : Tumeurs du sein.
- Adulte, Adulte d'âge moyen, Aisselle, Analyse de survie, Biopsie de noeud lymphatique sentinelle, Essais contrôlés randomisés comme sujet, Femelle, Humains, Ponction-biopsie à l'aiguille, Pronostic, Résultat thérapeutique, Stade de la tumeur, Sujet âgé, Survie sans rechute, Traitement néoadjuvant, Tumeurs du sein, Évaluation des risques.
English descriptors
- KwdEn :
- Adult, Aged, Antineoplastic Combined Chemotherapy Protocols (administration & dosage), Axilla, Biopsy, Needle, Breast Neoplasms (drug therapy), Breast Neoplasms (mortality), Breast Neoplasms (pathology), Breast Neoplasms (surgery), Disease-Free Survival, Female, Humans, Lymph Nodes (pathology), Middle Aged, Neoadjuvant Therapy, Neoplasm Staging, Prognosis, Randomized Controlled Trials as Topic, Risk Assessment, Sentinel Lymph Node Biopsy, Survival Analysis, Treatment Outcome.
- MESH :
- administration & dosage : Antineoplastic Combined Chemotherapy Protocols.
- drug therapy : Breast Neoplasms.
- mortality : Breast Neoplasms.
- pathology : Breast Neoplasms, Lymph Nodes.
- surgery : Breast Neoplasms.
- Adult, Aged, Axilla, Biopsy, Needle, Disease-Free Survival, Female, Humans, Middle Aged, Neoadjuvant Therapy, Neoplasm Staging, Prognosis, Randomized Controlled Trials as Topic, Risk Assessment, Sentinel Lymph Node Biopsy, Survival Analysis, Treatment Outcome.
Abstract
The most important determinant of prognosis for patients with breast cancer is the status of the axillary lymph nodes. Axillary lymph node dissection (ALND) has been performed for over a century to stage the cancer, achieve regional control, and perhaps improve survival. In accordance with tradition, ALND has been performed on all patients with the diagnosis of invasive breast cancer. In the early 1990s, this dogma was challenged because of the significant morbidity associated with ALND (paresthesia, extremity lymphedema) and the fact that greater than 50% of all breast cancers are node negative. A less morbid but highly accurate staging procedure, lymphatic mapping and sentinel lymph node biopsy (SNB) was introduced. Currently, the de facto standard of care in breast cancer is to perform LM and SNB in patients with small tumors and clinically negative axilla. While numerous methodological issues are being raised, the utility of LM and SNB identification continues to expand. In the current review we assess the application of this technique to locally advanced breast cancer (LABC) and neoadjuvant chemotherapy. What role does SNB play in locally advanced disease? Is LM and SNB accurate for patients with advanced disease? What influence do axillary metastases have on further treatment? What is the role of SNB in the planning for neoadjuvant patients? The skillful management of patients with breast cancer lies in the delicate balance between maximizing the efficacy of treatment and minimizing its morbidity and failure.
DOI: 10.1016/j.suronc.2003.08.002
PubMed: 14998567
Affiliations:
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Trocha</name><affiliation wicri:level="1"><nlm:affiliation>Joyce Eisenberg Keefer Breast Center, John Wayne Cancer Institute at Saint John's Health Center, 2200 Santa Monica Blvd. Suite, 113, Santa Monica, CA, 90404, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Joyce Eisenberg Keefer Breast Center, John Wayne Cancer Institute at Saint John's Health Center, 2200 Santa Monica Blvd. Suite, 113, Santa Monica, CA, 90404</wicri:regionArea><wicri:noRegion>90404</wicri:noRegion></affiliation></author><author><name sortKey="Giuliano, Armando E" sort="Giuliano, Armando E" uniqKey="Giuliano A" first="Armando E" last="Giuliano">Armando E. Giuliano</name></author></analytic><series><title level="j">Surgical oncology</title><idno type="ISSN">0960-7404</idno><imprint><date when="2003" type="published">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Antineoplastic Combined Chemotherapy Protocols (administration & dosage)</term><term>Axilla</term><term>Biopsy, Needle</term><term>Breast Neoplasms (drug therapy)</term><term>Breast Neoplasms (mortality)</term><term>Breast Neoplasms (pathology)</term><term>Breast Neoplasms (surgery)</term><term>Disease-Free Survival</term><term>Female</term><term>Humans</term><term>Lymph Nodes (pathology)</term><term>Middle Aged</term><term>Neoadjuvant Therapy</term><term>Neoplasm Staging</term><term>Prognosis</term><term>Randomized Controlled Trials as Topic</term><term>Risk Assessment</term><term>Sentinel Lymph Node Biopsy</term><term>Survival Analysis</term><term>Treatment Outcome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Aisselle</term><term>Analyse de survie</term><term>Biopsie de noeud lymphatique sentinelle</term><term>Essais contrôlés randomisés comme sujet</term><term>Femelle</term><term>Humains</term><term>Noeuds lymphatiques (anatomopathologie)</term><term>Ponction-biopsie à l'aiguille</term><term>Pronostic</term><term>Protocoles de polychimiothérapie antinéoplasique (administration et posologie)</term><term>Résultat thérapeutique</term><term>Stade de la tumeur</term><term>Sujet âgé</term><term>Survie sans rechute</term><term>Traitement néoadjuvant</term><term>Tumeurs du sein ()</term><term>Tumeurs du sein (anatomopathologie)</term><term>Tumeurs du sein (mortalité)</term><term>Tumeurs du sein (traitement médicamenteux)</term><term>Évaluation des risques</term></keywords><keywords scheme="MESH" qualifier="administration & dosage" xml:lang="en"><term>Antineoplastic Combined Chemotherapy Protocols</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Protocoles de polychimiothérapie antinéoplasique</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Noeuds lymphatiques</term><term>Tumeurs du sein</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Tumeurs du sein</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Breast Neoplasms</term><term>Lymph Nodes</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Tumeurs du sein</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Axilla</term><term>Biopsy, Needle</term><term>Disease-Free Survival</term><term>Female</term><term>Humans</term><term>Middle Aged</term><term>Neoadjuvant Therapy</term><term>Neoplasm Staging</term><term>Prognosis</term><term>Randomized Controlled Trials as Topic</term><term>Risk Assessment</term><term>Sentinel Lymph Node Biopsy</term><term>Survival Analysis</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Aisselle</term><term>Analyse de survie</term><term>Biopsie de noeud lymphatique sentinelle</term><term>Essais contrôlés randomisés comme sujet</term><term>Femelle</term><term>Humains</term><term>Ponction-biopsie à l'aiguille</term><term>Pronostic</term><term>Résultat thérapeutique</term><term>Stade de la tumeur</term><term>Sujet âgé</term><term>Survie sans rechute</term><term>Traitement néoadjuvant</term><term>Tumeurs du sein</term><term>Évaluation des risques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The most important determinant of prognosis for patients with breast cancer is the status of the axillary lymph nodes. Axillary lymph node dissection (ALND) has been performed for over a century to stage the cancer, achieve regional control, and perhaps improve survival. In accordance with tradition, ALND has been performed on all patients with the diagnosis of invasive breast cancer. In the early 1990s, this dogma was challenged because of the significant morbidity associated with ALND (paresthesia, extremity lymphedema) and the fact that greater than 50% of all breast cancers are node negative. A less morbid but highly accurate staging procedure, lymphatic mapping and sentinel lymph node biopsy (SNB) was introduced. Currently, the de facto standard of care in breast cancer is to perform LM and SNB in patients with small tumors and clinically negative axilla. While numerous methodological issues are being raised, the utility of LM and SNB identification continues to expand. In the current review we assess the application of this technique to locally advanced breast cancer (LABC) and neoadjuvant chemotherapy. What role does SNB play in locally advanced disease? Is LM and SNB accurate for patients with advanced disease? What influence do axillary metastases have on further treatment? What is the role of SNB in the planning for neoadjuvant patients? The skillful management of patients with breast cancer lies in the delicate balance between maximizing the efficacy of treatment and minimizing its morbidity and failure.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Giuliano, Armando E" sort="Giuliano, Armando E" uniqKey="Giuliano A" first="Armando E" last="Giuliano">Armando E. Giuliano</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Trocha, Steven D" sort="Trocha, Steven D" uniqKey="Trocha S" first="Steven D" last="Trocha">Steven D. Trocha</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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